Calcium L-5-Methyltetrahydrofolate: Advanced Bioactive Folate for Nutritional and Biomedical Research

1. Molecular Identity

• Chemical Name: Calcium (6S)-5-methyltetrahydrofolate
• CAS Number: 151533-22-1
• Source: Synthetically produced, metabolically active form of folate

2. Biochemical Significance

Calcium L-5-Methyltetrahydrofolate (L-5-MTHF) is the calcium salt of the biologically active form of folate. Its unique structure allows direct entry into the folate cycle, bypassing several metabolic steps required for folic acid. This property makes it a compound of significant interest in nutritional science, metabolic research, and potential therapeutic applications.

3. Key Properties

• High Bioavailability: Readily absorbed and utilized by the body
• Metabolic Efficiency: Directly usable in the folate cycle without conversion
• Methylation Support: Crucial for methylation processes in the body
• Genetic Compatibility: Beneficial for individuals with MTHFR polymorphisms

4. Potential Research Applications

• Nutritional supplementation studies
• Methylation and epigenetic research
• Neurological and psychiatric disorder investigations
• Cardiovascular health studies

5. Current Research Focus

Ongoing studies are investigating Calcium L-5-MTHF’s effects on:

• Depression and mood disorders
• Cognitive function and neuroprotection
• Cardiovascular disease risk factors
• Pregnancy outcomes and fetal development

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing stability in various supplement formulations
• Developing novel delivery systems for improved absorption
• Creating synergistic combinations with other nutrients

7. Regulatory Considerations

Calcium L-5-MTHF (CAS 151533-22-1) is recognized as a dietary ingredient in many countries. Its use in specific therapeutic applications may require additional regulatory approval depending on the jurisdiction and intended use.

8. Future Research Directions

The scientific community anticipates:

• Advanced clinical trials for neuropsychiatric indications
• Exploration of its role in personalized nutrition
• Investigation of potential interactions with genetic polymorphisms

9. Collaborative Opportunities

We invite nutritional scientists, neuroscientists, pharmaceutical researchers, and academic institutions to explore the research potential of Calcium L-5-Methyltetrahydrofolate. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at [email protected].

Join us in advancing nutritional and biomedical research with Calcium L-5-Methyltetrahydrofolate – a key player in folate metabolism and potential therapeutic interventions.