Cepharanthine: High-Purity Bisbenzylisoquinoline Alkaloid for Advanced Research Applications

1. Molecular Identity

• Chemical Name: (6aR,11aR,11cR)-7,8-dimethoxy-3,4-dimethyl-5H-6a,11a-(epoxyethano)dibenzo[a,g]quinolizine
• CAS Number: 481-49-2
• Source: Naturally found in Stephania cepharantha Hayata and other Stephania species

2. Biochemical Significance

Cepharanthine is a bisbenzylisoquinoline alkaloid widely studied for its bioactivity in oxidative stress, immune modulation, and cellular signaling. Its complex molecular structure has made it a subject of interest in phytochemical and biochemical research.

3. Key Properties of Cepharanthine

• Oxidative Stress Modulation: Studied for its radical-scavenging behavior
• Inflammatory Pathway Interaction: Explored in cell signaling studies
• Immune Response Regulation: Investigated for its immunomodulatory potential
• Cellular Protection: Evaluated in models of tissue stress

4. Potential Research Applications

• Inflammation and immune response studies
• Cell signaling and oxidative stress models
• Natural compound profiling in virology research
• Neurobiology and neuroprotection investigations

5. Current Research Focus

Active research directions include:

• Redox balance and antioxidant response pathways
• Cell culture experiments related to immune signaling
• Formulation and bioavailability enhancement techniques
• Neuroprotective mechanisms in in vitro systems

6. Formulation Challenges and Innovations

Researchers are focusing on:

• Solubility improvements for laboratory use
• Development of stable formulations for in vitro applications
• Synergistic use with other natural alkaloids

7. Bulk Availability and Technical Information

• Purity: ≥98% by HPLC
• Form: Yellowish crystalline powder
• Packaging: Available in laboratory and bulk quantities
• Documentation: COA, MSDS, and analytical data upon request

8. Compliance and Handling

Cepharanthine (CAS 481-49-2) is intended exclusively for laboratory research and analytical use. It is not approved for pharmaceutical, food, or cosmetic applications. Handle in accordance with standard laboratory safety protocols.

9. Future Research Directions

Emerging research topics include:

• Structure–activity relationship (SAR) mapping
• Advanced antioxidant screening systems
• Immune modulation studies using natural alkaloid models

10. Collaborative Opportunities

We welcome inquiries from researchers in phytochemistry, immunology, and cellular biology. For bulk requests, technical support, or partnership opportunities, please contact us at [email protected].

Partner with us in advancing scientific knowledge through Cepharanthine – a high-purity bisbenzylisoquinoline alkaloid supporting innovation in natural product research.