Evodiamine: Potent Alkaloid for Advanced Biomedical Research

1. Molecular Identity

• Chemical Name: (S)-3-Ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-one
• CAS Number: 518-17-2
• Molecular Formula: C19H17N3O
• Source: Naturally occurring in Evodia rutaecarpa, a traditional Chinese medicinal herb

2. Biochemical Significance

Evodiamine is a quinolone alkaloid with diverse biological activities. Its unique molecular structure contributes to its potential thermogenic, anti-inflammatory, and anticancer properties, making it a compound of significant interest in pharmaceutical research and traditional medicine studies.

3. Key Properties of Evodiamine

• Thermogenic: Exhibits ability to increase body temperature and metabolism
• Anti-inflammatory: Demonstrates potential to modulate inflammatory pathways
• Anticancer: Shows promise in inhibiting various cancer cell lines
• Cardiovascular: Indicates efficacy in improving vascular function

4. Potential Research Applications

• Obesity and weight management studies
• Cancer research and drug development
• Inflammatory disorder investigations
• Cardiovascular disease research

5. Current Research Focus

Ongoing studies are investigating Evodiamine’s effects on:

• Metabolic pathways related to thermogenesis and fat metabolism
• Cancer cell proliferation and apoptosis mechanisms
• Inflammatory signaling cascades in various tissues
• Vascular smooth muscle cell function and blood pressure regulation

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing bioavailability through novel delivery systems
• Developing targeted formulations for specific applications
• Creating synergistic combinations with other bioactive compounds

7. Regulatory Considerations

Evodiamine (518-17-2) is primarily used in research settings and traditional medicine. Its development for specific therapeutic applications would require comprehensive safety and efficacy evaluations to meet regulatory standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced clinical trials for obesity and metabolic disorders
• Exploration of Evodiamine’s potential in combination cancer therapies
• Investigation of its long-term effects on cardiovascular health

9. Collaborative Opportunities

We invite oncologists, endocrinologists, cardiovascular researchers, and academic institutions to explore the research potential of Evodiamine. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at [email protected].

Join us in advancing biomedical research with Evodiamine – a powerful alkaloid at the forefront of natural product-based therapeutic strategies.