Fangchinoline: Potent Bisbenzylisoquinoline Alkaloid for Advanced Natural Compound Research

1. Molecular Identity

• Chemical Name: (1S,1’S)-6,6′,12,12′-Tetramethoxy-2,2′-dimethylberbaman
• CAS Number: 436-77-1
• Molecular Formula: C₃₇H₄₀N₂O₆
• Source: Naturally occurring in Stephania tetrandra

2. Biochemical Significance

Fangchinoline is a bisbenzylisoquinoline alkaloid with a unique molecular scaffold. It is under active investigation for its potential roles in inflammation, cellular regulation, and neurological research models.

3. Key Properties of Fangchinoline

• Inflammation Modulation: In vitro studies show regulatory effects on cytokine pathways
• Cell Regulation: Investigated for impact on cellular proliferation and apoptosis
• Neuronal Models: Evaluated in systems related to neuroprotection
• Vascular Research: Studied in relation to endothelial and smooth muscle cell behavior

4. Potential Research Applications

• Oncology-related cell signaling investigations
• Neuroinflammation and oxidative stress models
• Vascular function and metabolic research
• Studies on bioactive alkaloid mechanisms

5. Current Research Focus

Ongoing studies explore:

• Mechanistic pathways in programmed cell death
• Role in central nervous system inflammation
• Calcium signaling in vascular tissues
• Combinatorial effects with related alkaloids

6. Formulation Challenges and Innovations

Research efforts aim to:

• Improve solubility and experimental delivery
• Enable targeted carrier systems in model systems
• Stabilize in various pH and oxidative environments

7. Bulk Availability and Technical Data

• Purity: ≥98% by HPLC
• Form: Light yellow powder
• Packaging: Research and bulk laboratory scale
• Documentation: COA, MSDS, and full specification sheets available upon request

8. Compliance and Handling

Fangchinoline (CAS 436-77-1) is intended for laboratory research use. All handling should follow institutional guidelines for experimental compounds. Not intended for human or animal consumption.

9. Future Research Directions

Expected developments include:

• In-depth exploration of its bioactivity in inflammation models
• Studies on neuronal function and oxidative pathways
• Further evaluation in multi-compound screening libraries

10. Collaborative Opportunities

We welcome partnerships with researchers in natural compound development, neurobiology, cell biology, and vascular studies. For bulk orders or technical discussions, contact us at [email protected].

Partner with NST Chemicals in exploring Fangchinoline – a structurally distinct bisbenzylisoquinoline alkaloid for next-generation research in inflammation, neurology, and cell regulation.