Fangchinoline: Potent Bisbenzylisoquinoline Alkaloid for Advanced Biomedical Research

1. Molecular Identity

• Chemical Name: (1S,1’S)-6,6′,12,12′-Tetramethoxy-2,2′-dimethylberbaman
• CAS Number: 436-77-1
• Molecular Formula: C37H40N2O6
• Source: Naturally occurring in Stephania tetrandra, a traditional Chinese medicinal herb

2. Biochemical Significance

Fangchinoline is a bisbenzylisoquinoline alkaloid with diverse biological activities. Its unique molecular structure contributes to its potential anti-inflammatory, antitumor, and neuroprotective properties, making it a compound of significant interest in pharmaceutical research and traditional medicine studies.

3. Key Properties of Fangchinoline

• Anti-inflammatory: Exhibits ability to modulate inflammatory responses
• Antitumor: Demonstrates potential against various cancer cell lines
• Neuroprotective: Shows promise in protecting neuronal cells
• Cardiovascular: Indicates efficacy in improving vascular function

4. Potential Research Applications

• Cancer research and drug development
• Neurodegenerative disorder studies
• Cardiovascular disease investigations
• Autoimmune and inflammatory condition research

5. Current Research Focus

Ongoing studies are investigating Fangchinoline’s effects on:

• Cancer cell signaling pathways and apoptosis mechanisms
• Neuroinflammatory processes in various brain disorders
• Vascular smooth muscle cell function and blood pressure regulation
• Immune system modulation and inflammatory mediators

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing bioavailability through novel delivery systems
• Developing targeted formulations for specific applications
• Creating synergistic combinations with other bioactive compounds

7. Regulatory Considerations

Fangchinoline (436-77-1) is primarily used in research settings and traditional medicine. Its development for specific therapeutic applications would require comprehensive safety and efficacy evaluations to meet regulatory standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced clinical trials for cancer and neurodegenerative disorders
• Exploration of Fangchinoline’s potential in combination therapies
• Investigation of its mechanisms of action at the molecular level

9. Collaborative Opportunities

We invite oncologists, neurologists, cardiovascular researchers, and academic institutions to explore the research potential of Fangchinoline. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at [email protected].

Join us in advancing biomedical research with Fangchinoline – a powerful bisbenzylisoquinoline alkaloid at the forefront of natural product-based therapeutic strategies.