L-Theanine (CAS 3081-61-6): Functional Amino Acid for Cognitive and Neurochemical Research

1. Molecular Identity

• Chemical Name: (2S)-2-Amino-5-(ethylamino)-5-oxopentanoic acid
• CAS Number: 3081-61-6
• Source: Naturally present in Camellia sinensis (tea leaves); also available via synthesis

2. Scientific Significance

L-Theanine is a naturally occurring amino acid structurally similar to glutamate. It is known for its ability to cross the blood-brain barrier and is widely researched for its role in neurotransmission, neurophysiological modulation, and functional ingredient formulation.

3. Research-Based Characteristics

• Neurochemical Interaction: Studied in models involving glutamatergic and dopaminergic systems
• Cognitive Modulation: Included in attention and focus-related experimental protocols
• Formulation Synergy: Explored in conjunction with caffeine and other nootropic compounds
• Non-sedative Relaxation Models: Used in stress resilience and calmness-oriented formulations

4. Application Areas

• Product development in cognitive and focus formulations
• Neuroscience research related to neurotransmitter modulation
• Supplement blends for mental clarity and performance support
• Botanical and amino acid-based functional ingredient systems

5. Current Research Themes

• Neurotransmitter balance and physiological response modeling
• Behavioral response evaluation under task-based conditions
• Sleep pattern support and circadian studies
• Cell-based neuroprotection assessments

6. Formulation Insights

• Enhanced Delivery: Work on increasing bioavailability and brain uptake
• Stability & Compatibility: Suitable for combination with other bioactives
• Release Mechanisms: Used in time-release and dual-action supplement formats

7. Regulatory Status

L-Theanine (CAS 3081-61-6) is Generally Recognized as Safe (GRAS) in the United States and is widely used in food supplements. Regulatory approval for specific health claims may vary by jurisdiction. Documentation is available to support formulation compliance.

8. Future Research Outlook

• Continued exploration in cognitive performance models
• Expanded combination research with functional botanicals and amino acids
• Neurobiological research on long-term mental function and aging

9. Collaboration and Bulk Supply

NST Chemicals offers high-purity L-Theanine for research and commercial product development. For bulk quantities, formulation advice, or collaborative inquiries, contact us at [email protected].

Unlock the potential of L-Theanine — a versatile amino acid supporting innovation in brain and wellness-focused formulations.