D-Mannitol: Versatile Sugar Alcohol for Advanced Biomedical Research

1. Molecular Identity

• Chemical Name: (2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexol
• CAS Number: 69-65-8
• Source: Naturally occurring in various plants and algae; also produced synthetically

2. Biochemical Significance

D-Mannitol is a sugar alcohol with unique properties that make it valuable in both medical and pharmaceutical research. Its osmotic properties and low reactivity contribute to its diverse uses in experimental and formulation contexts.

3. Key Properties of D-Mannitol

• Osmotic Diuretic: Effectively increases urine output and reduces intracranial pressure
• Excipient: Widely used in formulations as a bulking agent and sweetener
• Antioxidant: Demonstrates free radical scavenging activity
• Cryoprotectant: Protects cells during freeze-thaw processes

4. Potential Research Applications

• Neurological studies on intracranial pressure management
• Renal function and diuresis investigations
• Formulation development for active ingredients
• Cryopreservation technique optimization

5. Current Research Focus

Ongoing studies are investigating D-Mannitol’s effects on:

• Traumatic brain injury and cerebral edema
• Acute kidney injury and renal protection
• Enhanced delivery systems for research compounds
• Antioxidant therapies in various biological models

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Developing controlled-release compound formulations
• Enhancing stability in various experimental preparations
• Creating novel combinations for synergistic biological effects

7. Regulatory Considerations

D-Mannitol (CAS 69-65-8) is FDA-approved for various uses and is Generally Recognized as Safe (GRAS) as a food additive. Its use in specialized research applications should comply with applicable regulatory guidelines.

8. Future Research Directions

The scientific community anticipates:

• Advanced studies on neuroprotective mechanisms
• Exploration of D-Mannitol’s potential in targeted delivery systems
• Investigation of its role in managing oxidative stress-related conditions

9. Collaborative Opportunities

We invite neurologists, nephrologists, formulation scientists, and academic institutions to explore the research potential of D-Mannitol. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at [email protected].

Join us in advancing biomedical research with D-Mannitol – a versatile sugar alcohol at the forefront of neurological, renal, and formulation-based studies.