(S)-10-Hydroxycamptothecin: Potent Topoisomerase I Inhibitor for Advanced Cancer Research

1. Molecular Identity

• Chemical Name: (S)-4-ethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• CAS Number: 19685-09-7
• Source: Semi-synthetic derivative of camptothecin, originally isolated from Camptotheca acuminata

2. Biochemical Significance

(S)-10-Hydroxycamptothecin is a potent topoisomerase I inhibitor with enhanced solubility compared to its parent compound, camptothecin. Its unique structure and mechanism of action make it a compound of significant interest in cancer research and drug development.

3. Key Properties

• Topoisomerase I Inhibition: Potent activity against DNA topoisomerase I
• Anticancer Potential: Exhibits strong cytotoxicity against various cancer cell lines
• Improved Solubility: Enhanced aqueous solubility compared to camptothecin
• S-Configuration: Demonstrates superior biological activity over the R-isomer

4. Potential Research Applications

• Cancer drug development and optimization
• Structure-activity relationship studies of camptothecin analogues
• Investigation of topoisomerase I-mediated DNA damage and repair
• Development of novel drug delivery systems for camptothecin derivatives

5. Current Research Focus

Ongoing studies are investigating (S)-10-Hydroxycamptothecin’s effects on:

• Various cancer types, including drug-resistant tumors
• Combination therapies with other anticancer agents
• Nanoformulations for improved drug delivery
• Mechanisms of resistance to topoisomerase I inhibitors

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing stability of the active lactone form
• Developing targeted delivery systems for improved efficacy
• Creating prodrug formulations for optimized pharmacokinetics

7. Regulatory Considerations

As a research compound, (S)-10-Hydroxycamptothecin (CAS 19685-09-7) is primarily used in preclinical studies. Its development for therapeutic use would require extensive safety and efficacy evaluations to meet regulatory standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced preclinical and potential clinical trials for specific cancer indications
• Development of novel (S)-10-Hydroxycamptothecin conjugates and analogues
• Exploration of its potential in non-cancer applications, such as antiviral research

9. Collaborative Opportunities

We invite cancer researchers, medicinal chemists, pharmaceutical scientists, and academic institutions to explore the research potential of (S)-10-Hydroxycamptothecin. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at [email protected].

Join us in advancing cancer research with (S)-10-Hydroxycamptothecin – a key player in the development of next-generation topoisomerase I inhibitors.