(S)-10-Hydroxycamptothecin: Potent Topoisomerase I Inhibitor for Advanced Molecular Research

1. Molecular Identity

• Chemical Name: (S)-4-ethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• CAS Number: 19685-09-7
• Source: Semi-synthetic derivative of camptothecin, originally isolated from Camptotheca acuminata

2. Biochemical Significance

(S)-10-Hydroxycamptothecin is a potent topoisomerase I inhibitor with enhanced solubility compared to its parent compound, camptothecin. Its unique structure and mechanism of action make it a compound of significant interest in molecular and cellular research.

3. Key Properties

• Topoisomerase I Inhibition: Potent activity against DNA topoisomerase I
• Cellular Activity: Exhibits strong cytotoxicity against various cell lines
• Improved Solubility: Enhanced aqueous solubility compared to camptothecin
• S-Configuration: Demonstrates superior biological activity over the R-isomer

4. Potential Research Applications

• Small molecule optimization and screening platform development
• Structure-activity relationship studies of camptothecin analogues
• Investigation of topoisomerase I-mediated DNA interactions
• Development of targeted delivery systems for camptothecin derivatives

5. Current Research Focus

Ongoing studies are investigating (S)-10-Hydroxycamptothecin’s effects on:

• Various cell models, including resistant phenotypes
• Combination with other bioactive agents
• Nanoformulation strategies for enhanced delivery
• Mechanisms of response to topoisomerase I inhibition

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing stability of the active lactone form
• Developing targeted delivery systems for improved performance
• Designing modified analogues for optimized release profiles

7. Regulatory Considerations

As a research compound, (S)-10-Hydroxycamptothecin (CAS 19685-09-7) is intended for use in controlled laboratory settings. Any application beyond fundamental research requires compliance with applicable regulations and safety standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced in vitro and in vivo modeling for biological profiling
• Development of novel (S)-10-Hydroxycamptothecin analogues
• Exploration of potential applications beyond oncology models

9. Collaborative Opportunities

We invite molecular biologists, medicinal chemists, and academic institutions to explore the research potential of (S)-10-Hydroxycamptothecin. For inquiries, collaborations, or to discuss how this compound can support your scientific projects, please contact us at [email protected].

Join us in advancing cellular and molecular research with (S)-10-Hydroxycamptothecin – a key compound in the study of topoisomerase I inhibitors and their biological impact.