Ursodeoxycholic Acid: Potent Bile Acid for Advanced Hepatobiliary Research

1. Molecular Identity

• Chemical Name: 3α,7β-Dihydroxy-5β-cholan-24-oic acid
• CAS Number: 128-13-2
• Source: Naturally occurring in bear bile; also synthesized for pharmaceutical use

2. Biochemical Significance

Ursodeoxycholic Acid (UDCA) is a secondary bile acid with diverse therapeutic applications. Its unique molecular structure contributes to its hepatoprotective, choleretic, and cytoprotective properties, making it a compound of significant interest in hepatology, gastroenterology, and metabolic disorder research.

3. Key Properties of Ursodeoxycholic Acid

• Hepatoprotective: Demonstrates ability to protect liver cells from damage
• Choleretic: Shows potential in enhancing bile flow and composition
• Cytoprotective: Exhibits anti-apoptotic effects in various cell types
• Immunomodulatory: Indicates efficacy in modulating inflammatory responses

4. Potential Research Applications

• Cholestatic liver disease studies
• Gallstone dissolution investigations
• Non-alcoholic fatty liver disease (NAFLD) research
• Cystic fibrosis-associated liver disease studies

5. Current Research Focus

Ongoing studies are investigating Ursodeoxycholic Acid’s effects on:

• Bile acid signaling pathways
• Hepatic lipid metabolism
• Endoplasmic reticulum stress in liver cells
• Gut microbiome modulation

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing bioavailability through novel delivery systems
• Developing targeted formulations for specific hepatobiliary conditions
• Creating combination therapies with other hepatoprotective agents

7. Regulatory Considerations

Ursodeoxycholic Acid (CAS 128-13-2) is an FDA-approved drug for certain liver conditions. Its development for new therapeutic applications would require additional safety and efficacy evaluations to meet regulatory standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced clinical trials for emerging hepatobiliary disorders
• Exploration of UDCA’s potential in neurodegenerative diseases
• Investigation of its long-term effects on metabolic health

9. Collaborative Opportunities

We invite hepatologists, gastroenterologists, pharmacologists, and academic institutions to explore the research potential of Ursodeoxycholic Acid. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at [email protected].

Join us in advancing biomedical research with Ursodeoxycholic Acid – a powerful bile acid at the forefront of hepatobiliary and metabolic disorder research strategies.