Ursodeoxycholic Acid: High-Purity Bile Acid for Hepatobiliary Research

1. Molecular Identity

• Chemical Name: 3α,7β-Dihydroxy-5β-cholan-24-oic acid
• CAS Number: 128-13-2
• Source: Naturally occurring in small amounts in animal bile; commonly prepared via synthesis for research use

2. Biochemical Significance

Ursodeoxycholic Acid (UDCA) is a secondary bile acid of interest in hepatobiliary research. Its well-defined molecular structure is associated with studies on bile composition, cellular protection, and lipid regulation in hepatic models.

3. Key Research-Relevant Properties

• Cell Protection: Studied for its effects on liver cell resilience under stress
• Bile Modulation: Investigated for influence on bile acid flow and solubility
• Lipid Metabolism: Relevant for models exploring hepatic lipid pathways
• Inflammation Modulation: Explored in relation to immune and metabolic balance

4. Potential Research Applications

• Cholestasis and bile acid signaling studies
• In vitro models of gallstone formation and solubility
• Hepatic metabolism and liver function assessment
• Gut-liver axis and microbiome interaction research

5. Current Research Focus

Scientific studies are focusing on UDCA’s role in:

• Modulation of nuclear bile acid receptors
• Liver lipid accumulation and stress responses
• Impact on endoplasmic reticulum signaling pathways
• Interaction with gut microbiota in metabolic regulation

6. Formulation Challenges and Innovations

Ongoing work includes:

• Improving aqueous solubility for in vitro models
• Stability in varied pH environments
• Combination with other bile-related research compounds

7. Bulk Availability and Technical Data

• Purity: ≥98% (HPLC)
• Form: White to off-white crystalline powder
• Packaging: Available from research scale to bulk quantities
• Documentation: COA, MSDS, and analytical profile provided

8. Handling and Compliance

Ursodeoxycholic Acid (CAS 128-13-2) is offered for laboratory and research use only. Not intended for food, cosmetic, or clinical applications. Ensure standard laboratory handling procedures.

9. Future Research Directions

Emerging topics include:

• Long-term bile acid modulation in metabolic models
• Neuroprotective pathways involving bile acid derivatives
• Comparative analysis with other bile acid analogues

10. Collaborative Opportunities

We welcome inquiries from academic institutions, liver metabolism researchers, and formulation scientists. For bulk pricing, custom packaging, or collaboration requests, please contact us at [email protected].

Explore Ursodeoxycholic Acid as a valuable reference compound in hepatobiliary and bile acid pathway research.