Neohesperidin: Potent Flavanone Glycoside for Advanced Biomedical Research

1. Molecular Identity

• Chemical Name: (2S)-7-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one
• CAS Number: 13241-33-3
• Source: Naturally occurring in citrus fruits, particularly in bitter oranges (Citrus aurantium)

2. Biochemical Significance

Neohesperidin is a flavanone glycoside with diverse biological activities. Its unique molecular structure contributes to its potential antioxidant, anti-inflammatory, and cardiovascular protective properties, making it a compound of significant interest in pharmaceutical research and nutraceutical studies.

3. Key Properties of Neohesperidin

• Antioxidant: Exhibits strong free radical scavenging ability
• Anti-inflammatory: Demonstrates potential to modulate inflammatory pathways
• Cardiovascular Protection: Shows promise in improving vascular health
• Metabolic Regulation: Indicates efficacy in lipid and glucose metabolism

4. Potential Research Applications

• Cardiovascular disease studies
• Metabolic syndrome and diabetes research
• Inflammatory disorder investigations
• Neurodegenerative disease studies

5. Current Research Focus

Ongoing studies are investigating Neohesperidin’s effects on:

• Oxidative stress markers and antioxidant enzymes
• Inflammatory signaling pathways in various tissues
• Lipid profiles and glucose homeostasis
• Neuroprotective mechanisms in brain disorders

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing bioavailability through novel delivery systems
• Developing stable formulations for various applications
• Creating synergistic combinations with other bioactive compounds

7. Regulatory Considerations

Neohesperidin (CAS 13241-33-3) is primarily used in research settings and as a component in some dietary supplements. Its development for specific therapeutic applications would require comprehensive safety and efficacy evaluations to meet regulatory standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced clinical trials for cardiovascular and metabolic disorders
• Exploration of Neohesperidin’s potential in combination therapies
• Investigation of its mechanisms of action at the molecular level

9. Collaborative Opportunities

We invite cardiologists, endocrinologists, neurologists, and academic institutions to explore the research potential of Neohesperidin. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at [email protected].

Join us in advancing biomedical research with Neohesperidin– a powerful flavanone glycoside at the forefront of natural product-based therapeutic strategies.