Rutin: Potent Flavonoid Glycoside for Advanced Biomedical Research

1. Molecular Identity

• Chemical Name: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranosyloxy]-4H-chromen-4-one
• CAS Number: 153-18-4
• Source: Widely distributed in plants, particularly buckwheat, citrus fruits, and elderflower

2. Biochemical Significance

Rutin is a flavonoid glycoside with a wide range of biological activities. Its unique molecular structure, combining quercetin with a rutinose sugar, contributes to its potent antioxidant and anti-inflammatory properties, making it a compound of significant interest in nutritional and pharmaceutical research.

3. Key Properties of Rutin

• Antioxidant: Exhibits strong free radical scavenging activity
• Anti-inflammatory: Demonstrates ability to modulate inflammatory responses
• Vasoprotective: Shows potential in supporting vascular health
• Neuroprotective: Indicates promise in protecting neuronal cells

4. Potential Research Applications

• Cardiovascular disease studies
• Neurodegenerative disorder investigations
• Chronic venous insufficiency research
• Antioxidant-based therapies development

5. Current Research Focus

Ongoing studies are investigating rutin’s effects on:

• Oxidative stress-related cellular damage
• Inflammatory signaling pathways
• Blood vessel permeability and strength
• Neuroprotection mechanisms in various brain disorders

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing bioavailability and solubility
• Developing targeted delivery systems for improved efficacy
• Creating stable formulations for various research applications

7. Regulatory Considerations

Rutin (CAS 153-18-4) is generally recognized as safe (GRAS) as a food additive. Its use in specific therapeutic applications would require comprehensive safety and efficacy evaluations to meet regulatory standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced clinical trials for cardiovascular and neurological indications
• Exploration of rutin’s potential in combination therapies
• Investigation of structure-activity relationships for optimized derivatives

9. Collaborative Opportunities

We invite nutritionists, pharmacologists, neurologists, and academic institutions to explore the research potential of rutin. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at [email protected].

Join us in advancing biomedical research with rutin – a powerful flavonoid glycoside at the forefront of nutritional and pharmaceutical innovations.