Sodium Tauroglycocholate: Advanced Bile Salt for Biomedical and Pharmaceutical Research

1. Molecular Identity

• Chemical Name: Sodium 3α,7α,12α-trihydroxy-5β-cholan-24-oylglycine N-[2-sulfoethyl]amide
• CAS Number: 41945-48-6
• Source: Synthetic bile salt, combining properties of taurocholic and glycocholic acids

2. Biochemical Significance

Sodium tauroglycocholate is a synthetic bile salt that mimics the properties of naturally occurring bile acids. Its unique amphipathic structure and physiological relevance make it a compound of significant interest in various fields of biological and pharmaceutical research.

3. Key Properties

• Micelle Formation: Excellent capacity for forming mixed micelles
• Lipid Solubilization: Enhances solubility and absorption of lipids and lipophilic compounds
• Membrane Permeability: Influences cellular membrane permeability
• Bile Salt Transport: Models bile salt behavior in physiological systems

4. Potential Research Applications

• Drug absorption and bioavailability studies
• Lipid metabolism and cholesterol transport research
• Membrane biology investigations
• Pharmaceutical formulation development

5. Current Research Focus

Ongoing studies are investigating Sodium tauroglycocholate’s effects on:

• Enhanced oral drug delivery systems
• Intestinal permeability and absorption mechanisms
• Bile acid signaling pathways
• Interactions with the gut microbiome

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Developing stable formulations for various research applications
• Creating novel drug delivery systems utilizing bile salt properties
• Optimizing concentrations for specific research protocols

7. Regulatory Considerations

As a synthetic bile salt, Sodium tauroglycocholate (CAS 41945-48-6) is primarily used in research settings. Its use in pharmaceutical formulations would require thorough safety and efficacy evaluations to meet regulatory standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced studies on bile salt-mediated drug delivery mechanisms
• Exploration of its potential in personalized medicine approaches
• Development of novel formulations for poorly soluble drugs

9. Collaborative Opportunities

We invite pharmaceutical researchers, biophysicists, gastroenterologists, and academic institutions to explore the research potential of Sodium tauroglycocholate. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at sales@nstchemicals.com.

Join us in advancing biological and pharmaceutical research with Sodium tauroglycocholate – a versatile synthetic bile salt at the forefront of drug delivery and absorption studies.