Taurochenodesoxycholic Acid: Advanced Bile Acid for Metabolic and Hepatic Research

1. Molecular Identity

• Chemical Name: 3α,7α-Dihydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide
• CAS Number: 516-35-8
• Source: Naturally occurring bile acid, also synthetically produced

2. Biochemical Significance

Taurochenodesoxycholic acid (TCDCA) is a conjugated bile acid that plays crucial roles in lipid metabolism and cellular signaling. Its unique properties make it a compound of significant interest in hepatology, gastroenterology, and metabolic research.

3. Key Properties

• Lipid Emulsification: Facilitates dietary fat absorption
• Cell Signaling: Acts as a signaling molecule in various physiological processes
• Cytoprotective Effects: Demonstrates potential in protecting liver cells
• Metabolic Regulation: Involved in glucose and lipid homeostasis

4. Potential Research Applications

• Liver disease studies
• Metabolic syndrome and diabetes research
• Bile acid signaling pathway investigations
• Drug solubilization and delivery system development

5. Current Research Focus

Ongoing studies are investigating TCDCA’s effects on:

• Non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH)
• Insulin sensitivity and glucose metabolism
• Inflammatory bowel conditions
• Bile acid-activated receptors and their downstream effects

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing stability in various experimental conditions
• Developing targeted delivery systems for improved efficacy
• Creating synergistic combinations with other therapeutic agents

7. Regulatory Considerations

As a naturally occurring bile acid, TCDCA (CAS 516-35-8) is generally considered safe for research use. Any therapeutic applications would require specific regulatory approvals based on safety and efficacy data.

8. Future Research Directions

The scientific community anticipates:

• Advanced clinical trials for liver and metabolic disorders
• Exploration of TCDCA’s potential in neuroprotection
• Development of novel TCDCA-based drug delivery systems

9. Collaborative Opportunities

We invite hepatologists, gastroenterologists, metabolic researchers, and academic institutions to explore the research potential of Taurochenodesoxycholic acid. For inquiries, collaborations, or to discuss how TCDCA can benefit your research projects, please contact us at sales@nstchemicals.com.

Join us in advancing hepatic and metabolic research with Taurochenodesoxycholic acid – a key bile acid at the forefront of innovative therapeutic strategies.