Chenodeoxycholic Acid: Essential Bile Acid for Advanced Hepatic and Metabolic Research

1. Molecular Identity

• Chemical Name: 3α,7α-Dihydroxy-5β-cholan-24-oic acid
• CAS Number: 474-25-9
• Source: Naturally occurring primary bile acid in humans and other mammals

2. Biochemical Significance

Chenodeoxycholic Acid is a primary bile acid with crucial roles in lipid metabolism and cellular signaling. Its unique properties make it a compound of significant interest in hepatology, gastroenterology, and metabolic research.

3. Key Properties of Chenodeoxycholic Acid

• Lipid Emulsifier: Facilitates dietary fat absorption and cholesterol solubilization
• FXR Agonist: Activates the Farnesoid X Receptor, influencing metabolic pathways
• Cholesterol Regulator: Plays a role in cholesterol homeostasis and gallstone prevention
• Cell Signaling Modulator: Influences various cellular processes through bile acid signaling

4. Potential Research Applications

• Liver disease studies, particularly for cholestatic conditions
• Metabolic syndrome and diabetes investigations
• Gallstone dissolution research
• Gut microbiome and bile acid metabolism studies

5. Current Research Focus

Ongoing studies are investigating Chenodeoxycholic Acid’s effects on:

• Non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH)
• Glucose and lipid metabolism regulation
• Intestinal barrier function and permeability
• Bile acid-activated receptor signaling pathways

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Developing targeted delivery systems to enhance efficacy and reduce side effects
• Creating stable formulations for various research applications
• Exploring synthetic analogues with improved pharmacological profiles

7. Regulatory Considerations

Chenodeoxycholic Acid (CAS 474-25-9) is FDA-approved for certain cholestatic liver diseases. Its use in research should comply with relevant regulations and guidelines.

8. Future Research Directions

The scientific community anticipates:

• Advanced clinical trials for metabolic and hepatic indications
• Exploration of Chenodeoxycholic Acid’s potential in combination therapies
• Investigation of its role in gut-liver axis modulation

9. Collaborative Opportunities

We invite hepatologists, gastroenterologists, metabolic researchers, and academic institutions to explore the research potential of Chenodeoxycholic Acid. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at [email protected].

Join us in advancing biomedical research with Chenodeoxycholic Acid – a crucial bile acid at the intersection of hepatic, metabolic, and gastrointestinal studies.