Diacetyl Boldine: Multifaceted Alkaloid Derivative for Advanced Research

1. Molecular Identity

• Chemical Name: (R)-1,10-Diacetoxy-2,9-dimethoxy-aporphine
• CAS Number: 72584-75-9
• Source: Semi-synthetic derivative of boldine, an alkaloid found in Peumus boldus (boldo tree)

2. Biochemical Significance

Diacetyl boldine is a modified form of boldine, featuring acetyl groups that alter its pharmacological profile. This structural modification enhances certain properties of the parent compound, making it a subject of interest in pharmaceutical research and potential therapeutic applications.

3. Key Properties

• Enhanced Lipophilicity: Improved membrane permeability compared to boldine
• Antioxidant Activity: Exhibits free radical scavenging capabilities
• Potential Neuroprotection: Shows promise in protecting neuronal cells
• Cardiovascular Effects: Demonstrates potential in vascular health

4. Potential Research Applications

• Neurodegenerative disease studies
• Cardiovascular research
• Antioxidant and free radical investigations
• Drug delivery system development

5. Current Research Focus

Ongoing studies are investigating Diacetyl boldine’s effects on:

• Neuroprotection mechanisms in various brain disorders
• Vascular smooth muscle cell function
• Oxidative stress-induced cellular damage
• Potential anti-inflammatory properties

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing stability in various experimental conditions
• Developing novel delivery systems for improved bioavailability
• Creating synergistic combinations with other neuroprotective agents

7. Regulatory Considerations

As a semi-synthetic compound, Diacetyl boldine (CAS 72584-75-9) is primarily used in research settings. Any potential therapeutic applications would require extensive safety and efficacy evaluations to meet regulatory standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced preclinical studies for specific neurological indications
• Exploration of Diacetyl boldine’s potential in combination therapies
• Investigation of structure-activity relationships for optimized derivatives

9. Collaborative Opportunities

We invite neuroscientists, pharmacologists, medicinal chemists, and academic institutions to explore the research potential of Diacetyl boldine. For inquiries, collaborations, or to discuss how Diacetyl boldine can benefit your research projects, please contact us at sales@nstchemicals.com.

Join us in advancing the frontiers of alkaloid research with Diacetyl boldine – a promising compound at the intersection of natural product chemistry and modern pharmacological innovation.