Huperzine A: Potent Alkaloid for Advanced Neuropharmacological Research

1. Molecular Identity

• Chemical Name: (1R,9S,13E)-1-amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.0²,⁷]trideca-2(7),3,10-trien-5-one
• CAS Number: 102518-79-6
• Source: Isolated from the Chinese club moss Huperzia serrata

2. Biochemical Significance

Huperzine A is a sesquiterpene alkaloid with potent acetylcholinesterase inhibition properties. Its unique molecular structure contributes to its high selectivity and long-lasting action, making it a compound of significant interest in neuropharmacological research and potential therapeutic applications.

3. Key Properties of Huperzine A

• Acetylcholinesterase Inhibitor: Potently and selectively inhibits AChE
• Neuroprotective: Demonstrates potential in protecting neuronal cells
• Cognitive Enhancer: Shows promise in improving memory and learning
• NMDA Receptor Antagonist: Exhibits additional neuroprotective mechanisms

4. Potential Research Applications

• Alzheimer’s disease studies
• Cognitive enhancement investigations
• Neuroprotection research
• Memory and learning mechanism studies

5. Current Research Focus

Ongoing studies are investigating Huperzine A’s effects on:

• Neurodegenerative disorders, particularly Alzheimer’s disease
• Cognitive function in healthy individuals
• Neuroprotection against various forms of brain injury
• Potential applications in treating myasthenia gravis

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing bioavailability and blood-brain barrier penetration
• Developing sustained-release formulations
• Creating novel drug delivery systems for targeted action

7. Regulatory Considerations

Huperzine A (CAS 102518-79-6) is currently used as a dietary supplement in some countries. Its development for specific therapeutic applications would require comprehensive safety and efficacy evaluations to meet regulatory standards.

8. Future Research Directions

The scientific community anticipates:

• Advanced clinical trials for neurodegenerative disorders
• Exploration of Huperzine A’s potential in combination therapies
• Investigation of long-term effects on brain health and cognition

9. Collaborative Opportunities

We invite neuropharmacologists, cognitive scientists, and academic institutions to explore the research potential of Huperzine A. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at sales@nstchemicals.com.

Join us in advancing neuropharmacological research with Huperzine A – a powerful alkaloid at the forefront of cognitive enhancement and neuroprotection studies.