Shikimic Acid: Essential Precursor for Advanced Biochemical Research

1. Molecular Identity

• Chemical Name: (3R,4S,5R)-3,4,5-Trihydroxycyclohexene-1-carboxylic acid
• CAS Number: 138-59-0
• Source: Naturally occurring in star anise and other plants; also produced by microbial fermentation

2. Biochemical Significance

Shikimic acid is a key intermediate in the biosynthesis of aromatic amino acids in plants and microorganisms. Its unique structure and role in the shikimate pathway make it a compound of significant interest in biochemical research, particularly in the development of antibiotics and herbicides.

3. Key Properties of Shikimic Acid

• Biosynthetic Precursor: Essential for aromatic amino acid synthesis
• Antiviral Potential: Serves as a starting material for oseltamivir phosphate (Tamiflu)
• Metabolic Pathway Marker: Useful in studying the shikimate pathway
• Antioxidant: Exhibits free radical scavenging activity

4. Potential Research Applications

• Antiviral drug development studies
• Plant metabolism investigations
• Herbicide resistance research
• Microbial fermentation optimization

5. Current Research Focus

Ongoing studies are investigating shikimic acid’s role in:

• Novel antiviral compound synthesis
• Metabolic engineering of plants and microorganisms
• Development of new herbicides targeting the shikimate pathway
• Exploration of potential health benefits in humans

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Improving extraction and purification methods
• Developing sustainable production techniques
• Creating stable formulations for various research applications

7. Regulatory Considerations

Shikimic acid (CAS 138-59-0) is primarily used in research and as a precursor in pharmaceutical manufacturing. Its use in specific applications may be subject to regulatory oversight depending on the intended use and jurisdiction.

8. Future Research Directions

The scientific community anticipates:

• Advanced studies on shikimic acid derivatives for various therapeutic applications
• Exploration of its potential in combating drug-resistant pathogens
• Investigation of novel biosynthetic pathways for shikimic acid production

9. Collaborative Opportunities

We invite biochemists, pharmacologists, plant biologists, and academic institutions to explore the research potential of shikimic acid. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at sales@nstchemicals.com.

Join us in advancing biochemical research with shikimic acid – a crucial intermediate at the intersection of plant metabolism and pharmaceutical innovation.