Xanthohumol: Harnessing Nature’s Potent Prenylated Flavonoid

1. Molecular Identity

• Chemical Name: 3-[3,5-Dihydroxy-2-(3-methylbut-2-en-1-yl)phenyl]-1-(2,4-dihydroxyphenyl)prop-2-en-1-one
• CAS Number: 6754-58-1
• Source: Primarily isolated from the female inflorescences of Humulus lupulus (hops)

2. Biochemical Significance

Xanthohumol is a prenylated chalcone with a unique molecular structure that contributes to its diverse biological activities. As the principal prenylated flavonoid in hops, it has garnered significant interest in both the brewing industry and biomedical research for its potential health benefits.

3. Key Therapeutic Properties

• Antioxidant: Exhibits potent free radical scavenging activity
• Anti-inflammatory: Demonstrates ability to modulate inflammatory pathways
• Anticancer: Shows promise in inhibiting various cancer cell types
• Metabolic Modulator: Indicates potential benefits for metabolic health

4. Potential Applications

• Cancer research and chemoprevention studies
• Cardiovascular health investigations
• Metabolic syndrome and diabetes research
• Nutraceutical and functional food development

5. Current Research Focus

Ongoing studies are investigating Xanthohumol’s effects on:

• Various cancer types and mechanisms of action
• Oxidative stress and inflammatory processes
• Glucose and lipid metabolism
• Neuroprotection and cognitive function

6. Formulation Challenges and Innovations

Researchers and formulators are actively working on:

• Enhancing bioavailability through novel delivery systems
• Developing stable formulations for various applications
• Creating synergistic combinations with other bioactive compounds

7. Regulatory Considerations

Xanthohumol (CAS CAS 6754-58-1) is naturally present in hops and beer. Its use in dietary supplements and functional foods is subject to regulatory oversight. Therapeutic applications would require extensive safety and efficacy evaluations.

8. Future Directions

The scientific and industrial community anticipates:

• Advanced clinical trials for specific health indications
• Development of Xanthohumol-enriched functional foods and beverages
• Exploration of synthetic analogues with enhanced properties

9. Collaborative Opportunities

We invite researchers, pharmaceutical companies, nutraceutical developers, and brewing industry professionals to explore the potential of Xanthohumol. For inquiries, collaborations, or to discuss how Xanthohumol can benefit your research or product development, please contact us at sales@nstchemicals.com.

Join us in unlocking the full potential of Xanthohumol – a versatile prenylated flavonoid bridging traditional brewing wisdom with cutting-edge biomedical research.