Veratramine: Potent Steroidal Alkaloid for Advanced Pharmacological Research

1. Molecular Identity

• Chemical Name: (3β,23R)-14,15,16,17-Tetradehydro-3-hydroxyveratraman-11-one
• CAS Number: 60-70-8
• Source: Isolated from various Veratrum species, particularly Veratrum album and Veratrum viride

2. Biochemical Significance

Veratramine is a steroidal alkaloid with a complex molecular structure. Its presence in Veratrum species and its potent biological activities make it a compound of significant interest in natural product research, pharmacology, and potential therapeutic applications.

3. Key Properties

• Hypotensive Effect: Demonstrates potential in lowering blood pressure
• Ion Channel Modulation: Interacts with various ion channels, particularly sodium channels
• Teratogenic Activity: Exhibits embryotoxic effects (important for developmental biology research)
• Structural Complexity: Features a unique steroidal skeleton with multiple functional groups

4. Potential Research Applications

• Cardiovascular pharmacology studies
• Ion channel research and electrophysiology
• Developmental biology and teratology investigations
• Natural product chemistry and structure-activity relationship studies

5. Current Research Focus

Ongoing studies are investigating Veratramine’s effects on:

• Mechanisms of blood pressure regulation
• Sodium channel dynamics and neuronal excitability
• Embryonic development pathways (for research purposes only)
• Potential anticancer properties in certain cell lines

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Developing targeted delivery systems to enhance specificity
• Creating stable formulations for various research applications
• Exploring structure-activity relationships to design safer analogues

7. Regulatory Considerations

Due to its potent biological effects and teratogenic potential, Veratramine (CAS 60-70-8) is primarily used in research settings. Any therapeutic applications would require extensive safety evaluations and regulatory approvals.

8. Future Research Directions

The scientific community anticipates:

• Advanced studies on the molecular mechanisms of Veratramine’s biological activities
• Development of Veratramine-inspired compounds with improved safety profiles
• Further elucidation of its role in plant defense mechanisms

9. Collaborative Opportunities

We invite pharmacologists, neuroscientists, developmental biologists, and academic institutions to explore the research potential of Veratramine. For inquiries, collaborations, or to discuss how Veratramine can benefit your research projects, please contact us at sales@nstchemicals.com.

Join us in advancing pharmacological research with Veratramine – a complex steroidal alkaloid at the forefront of natural product and biomedical investigations.