N-Acetyltizanidine: Advanced Metabolite for Pharmaceutical Research

1. Molecular Identity

• Chemical Name: N-[4-(2-Imidazolin-2-ylamino)-2,6-dichlorophenyl]acetamide
• CAS Number: 173532-15-5
• Source: Metabolite of tizanidine, synthetically produced for research purposes

2. Biochemical Significance

N-Acetyltizanidine is a significant metabolite of tizanidine, a centrally acting α2-adrenergic agonist. Its unique molecular structure provides valuable insights into tizanidine metabolism and pharmacokinetics, making it a compound of considerable interest in pharmaceutical research and drug metabolism studies.

3. Key Properties of N-Acetyltizanidine

• Metabolic Marker: Serves as an important indicator of tizanidine metabolism
• Pharmacokinetic Studies: Useful in understanding tizanidine’s metabolic pathway
• Potential Bioactivity: May contribute to the overall pharmacological effects of tizanidine
• Analytical Standard: Vital for developing and validating analytical methods

4. Potential Research Applications

• Drug metabolism and pharmacokinetic studies
• Bioanalytical method development and validation
• Toxicological investigations related to tizanidine
• Structure-activity relationship studies in α2-adrenergic agonists

5. Current Research Focus

Ongoing studies are investigating N-Acetyltizanidine’s role in:

• Tizanidine metabolism and drug-drug interactions
• Development of improved analytical techniques for metabolite detection
• Understanding individual variations in tizanidine response
• Exploring potential therapeutic applications of metabolites

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing stability for long-term storage and analysis
• Developing standardized formulations for research applications
• Creating deuterated analogs for use in mass spectrometry studies

7. Regulatory Considerations

N-Acetyltizanidine (CAS 173532-15-5) is primarily used in research settings. Its use in specific applications may be subject to regulatory oversight depending on the intended use and jurisdiction.

8. Future Research Directions

The scientific community anticipates:

• Advanced studies on the pharmacological activity of tizanidine metabolites
• Exploration of N-Acetyltizanidine as a potential biomarker
• Investigation of its role in personalized medicine approaches for tizanidine therapy

9. Collaborative Opportunities

We invite pharmacologists, analytical chemists, toxicologists, and academic institutions to explore the research potential of N-Acetyltizanidine. For inquiries, collaborations, or to discuss how this compound can benefit your research projects, please contact us at sales@nstchemicals.com.

Join us in advancing pharmaceutical research with N-Acetyltizanidine – a key metabolite at the forefront of drug metabolism and pharmacokinetic studies.